binding to AT1R, leads to increased production of superoxide anions and impairs glucose-stimulated insulin secretion (GSIS) and insulin signalling, the contribution of alternative RAS-axes to beta cell [...] conversion of AngII to AngIV and, thereby, generate the ligand for IRAP/AT4R, were equally elevated in response to high glucose. IRAP/AT4R is trans-located from intracellular GLUT4-vesicles to the surface in [...] insulin-regulated AP (IRAP) [1]. Exposure of BRIN-BD11 cells to high glucose increased cardiolipin oxidation and cytochrome c release in parallel to compromising mitochondrial membrane fluidity [2]. Notably

https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2014/project-c2-lendeckel/

Bayesian and computational statistics applied to change detection in multimodal time series. Together with collaborators, Alexandra worked on models to enable a robot to interact and learn in its environment based [...] that enables to build a multitude of three-dimensional shape patterns (see figure below: Modular Haptic Stimulus Board). Alexandra used MHSB to design a novel set of haptic puzzles, and to investigate, [...] environment with distractor items. An intelligent tutoring interface used to teach to play piano. The GUI shows a piece of music score to the learner. The exoskeleton Dexmo on the hand demonstrates the correct

https://datascience.uni-greifswald.de/team/alexandra-moringen/

ts in cell cultures. The investigation of the metabolic adaptation of organisms to the environment and their response to stress conditions is a challenging task. Only by a comprehensive characterization [...] studies with respect to the impact of antioxidative compounds. The planned studies will reveal how radical scavengers can be assayed yielding biologically relevant results that will allow to understand, how [...] radical scavengers act in living cells (with respect to chemical target molecules and subcellular organelles). For membrane protection it is important to know, which components of plant extracts contain maximal

https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2014/project-b4-kahlert-lalk/

Python, R and Julia. Our goal is to equip students with the necessary skills for data-driven research. Students will learn how to collect, process, analyze, and interpret data to make data-driven decisions. [...] Master of Science in Data Science program, designed to foster innovation and interdisciplinary research. Our program is designed for those looking to explore the intersection of data science with various [...] data mining, and predictive analytics—with domain-specific knowledge, encouraging students to apply data science to a wide range of real-world problems. Capstone Research Projects : Throughout the program

https://datascience.uni-greifswald.de/lehre/

site, which is also present in the promoter of the Fat1 gene. Fat1 has been suggested to link mitochondrial activity to cell growth. The pharmacological modulation of the signaling pathway activity targeting [...] mechanisms contributing to the TAZ-KO-mediated effects. Mitochondrial structure and function will be determined in collaboration with Profs. Scholz and Helm and will be correlated to cardiolipin composition [...] metabolism and growth; however, physiologic mechanisms that control mitochondrial activity and translate it to cellular dysfunction in disease conditions and ageing remain incompletely understood[2]. In collaborative

https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2017/project-c2-lendeckel/

Daniel Lehmann Contact Daniel Lehmann Institut für Mathematik und Informatik Walther-Rathenau-Str. 47 17489 Greifswald Phone +49 3834 420 4662 daniel.lehmannuni-greifswaldde Short Biography Daniel Lehmann [...] learning, out-of-distribution detection, and adversarial attacks. He holds a Diplom degree (comparable to a Master degree) in Business Computer Science from the University of Rostock. Publications Daniel Lehmann [...] 493--500, 2022. [ Paper ] Daniel Lehmann and Marc Ebner Layer-Wise Activation Cluster Analysis of CNNs to Detect Out-of-Distribution Samples . In Igor Farkas, Paolo Masulli, Sebastian Otte and Stefan Wermter

https://math-inf.uni-greifswald.de/institut/ueber-uns/mitarbeitende/daniel-lehmann/

on) On the second day you learn how to prepare the reading process efficiently and how to develop flexible reading strategies facilitating an individual approach to each text – taking into consideration [...] on) On the second day you learn how to prepare the reading process efficiently and how to develop flexible reading strategies facilitating an individual approach to each text – taking into consideration [...] Venue: Friedrich-Loeffler-Straße 70, Room 1 The course is already fully booked. To register on the waiting list, please contact graduiertenakademie.uni-greifswald.de The number of participants is limited.

https://www.uni-greifswald.de/forschung/wissenschaftlicher-nachwuchs/graduiertenakademie/kurse-und-veranstaltungen/archiv-2015/improved-reading-2015/

"Greifswald" from motorway A20 to road B109 in the direction of Greifswald. Continue straight to Grimmer Landstraße (L26) and turn right to Loitzer Landstraße. Take the first turn left to Soldmannstraße and continue [...] passing the archway. Copyright Copyright The author intended not to use any copyrighted material for the publication or, if not possible, to indicate the copyright of the respective object. The copyright [...] Cytology and Evolutionary Biology Welcome to the website of the Department for Cytology and Evolutionary Biology! Here, you find information about current and former members, research activities, applied

https://zoologie.uni-greifswald.de/struktur/abteilungen/cytology-and-evolutionary-biology/

as molecular area. Goal: We plan to investigate how the changes on a molecular level influence 2D phase separation. In a first step we need to find a reliable method to quantify the amount of oxidative [...] mixtures and increasing the complexity to approach mitochondrial membranes (with C2). Work Plan: A low temperature plasma jet (kINPen®) will be used to form reactive species. To quantity the effect of produced [...] lipid monolayers, which are especially suitable to study 2D phase separation which may underlie the raft hypothesis of cell membrane organization [3] . Similar to natural membranes the monolayers are composed

https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2017/project-b1-helm/

will lead to necrosis of pancreatic acinar cells and subsequently to systemic inflammation [1;2;3]. Recently, we were able to show that the proinflammatory cytokine TNF alpha alone is able to induce premature [...] compartment in which they are generated needs to be determined. Radical scavengers such as NAC or more specific inhibitors such as L-Nil or L-Name will be used to specify the nature of ROS. In NADPH knock-out [...] catalytic conditions of cathepsin B and L depend on radicals, pH and endogenous inhibitors. We aim to determine the role of reactive oxygen species on enzyme activity of cysteine proteases in the secretory

https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2014/project-a3-mayerle/