analysis to identify distinct mutations present in tafazzins and to guide protein engineering of these enzymes to improve our understanding of sequence-function relationships. Furthermore, we plan to investigate [...] special emphasis given to ROS formation. This project aims to provide important insights into the metabolic role of tafazzin(s) in cardiolipin modification and its susceptibility to ROS. Literature [1.] [...] Cardiolipin (CL), the only phospholipid specific to mitochondria. Mutations in the human tafazzin cause the Barth syndrome[ 1] , a disease that is connected to cardiomyopathy, skeletal muscle weakness, fatigue
https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2017/project-a2-bornscheuer/