proximity to the membrane surface [2]. Intermediate extended conformations with a closed head correspond to activated state integrin, where the conformational changes in the extracellular domain lead to increased [...] (FRET) will be used to prove whether or not α IIb β 3 is activated . In addition, antibodies which recognize the activated α IIb β 3 will be used in an enzyme immunosorbent assay to validate protein activation [...] Background Integrins are an important family of transmembrane adhesion receptors that mediate cell adhesion to the extracellular matrix proteins, or cell-cell interaction. AlphaIIbbeta3 ( αIIbβ3) is the most abundant
https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2017/project-b6-delcea/