binding to AT1R, leads to increased production of superoxide anions and impairs glucose-stimulated insulin secretion (GSIS) and insulin signalling, the contribution of alternative RAS-axes to beta cell [...] conversion of AngII to AngIV and, thereby, generate the ligand for IRAP/AT4R, were equally elevated in response to high glucose. IRAP/AT4R is trans-located from intracellular GLUT4-vesicles to the surface in [...] insulin-regulated AP (IRAP) [1]. Exposure of BRIN-BD11 cells to high glucose increased cardiolipin oxidation and cytochrome c release in parallel to compromising mitochondrial membrane fluidity [2]. Notably
https://physik.uni-greifswald.de/dfg-forschungsverbuende/biox/1st-funding-period/projects-2014/project-c2-lendeckel/